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What are the advantages (if any) to cleaning under pressure vs. not?

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When using acid and detergent(s), cleaning under pressure is feasible - however, cleaning-in-place (CIP) with caustic is not recommended under pressure, as it absorbs the majority of the CO2 in the tank, creating a vacuum and potentially causing the tank to implode. The caustic is also converted to bicarbonate ion upon absorption of the CO2, causing it to be extremely ineffective in the CIP process overall. 

As an alternative, cleaning tanks under pressure with acid (even doing so every other time you CIP) can save both time and reduce the overall amount of CO2 needed in your brewery.

Be sure to monitor the temperature of the tank. Heat cleaning without reliable pressure relief valves (PRV(s)) can put the tanks at risk of imploding. 
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